Lady Hiss is a green rattlesnake who dons a viking helmet, earrings, and a red dress. She has a long tongue and red irises.
Lady Hiss has a laid-back and calm and cool demeanor often conversing with her friends. she speaks with casual mannerisms and tries to avoid confrontations. She speaks with a minor lisp as well.
In her first appearance, Cleanliness Is Next to Grupliness, she has a chat with Skullivan. The two became disgusted by Grup's smell and instead of telling him, she suggests the idea of covering their noses. She later pokes fun of Skullivan's predicament of having a ham stuck in his nose hole.